Doubt, majority, and profit expectation

Regarding what we talked about Pascal’s Wager, you said that if you are faced with a decision that has a small chance of something serious happening, you think you should go with the odds without considering the expected profit (since the experiment is a one-time experiment).
But in the world of Halacha, there is a great rule, doubt from the Torah to the grave, meaning that even if the majority of the poskim (or most of the chances) permit something, we still follow the small chance (or minority of poskim) that it is forbidden (there are exceptions to the rule and doubt is a possibility). The reason we follow the minority, I assume, is because the expectation of profit (or loss) is still significant and therefore it is what ultimately influences the decision (even though the experiment here is also a one-time one).